diff --git a/dev-python/python-binary-memcached/Manifest b/dev-python/python-binary-memcached/Manifest
deleted file mode 100644
index c53caf703c..0000000000
--- a/dev-python/python-binary-memcached/Manifest
+++ /dev/null
@@ -1 +0,0 @@
-DIST python-binary-memcached-0.31.1-gh.tar.gz 93809 BLAKE2B 6a7a6921a7ff24427ddb5443acf7a81c43a06baaadaead9caf50a8eb758d05d43430dd581e69d6dd4e83799e52e93949250cbf69309bb860857c63972ad0fc2c SHA512 3fbf0cbf05b42a5e28f01542ff0d190d138104cab97a5b05c17133f245fe37aad97b4daba31c203d854a4228fc9d49fd0306d93a45541a8cf7d173afc81c70ab
diff --git a/dev-python/python-binary-memcached/metadata.xml b/dev-python/python-binary-memcached/metadata.xml
deleted file mode 100644
index 399b6e3379..0000000000
--- a/dev-python/python-binary-memcached/metadata.xml
+++ /dev/null
@@ -1,16 +0,0 @@
-<?xml version="1.0" encoding="UTF-8"?>
-<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
-<pkgmetadata>
-	<maintainer type="person">
-		<email>lssndrbarbieri@gmail.com</email>
-		<name>Alessandro Barbieri</name>
-	</maintainer>
-	<longdescription lang="en">
-A pure python module (thread safe) to access memcached via it's binary with SASL auth support.
-The main purpose of this module it to be able to communicate with memcached using binary protocol and support authentication, so it can work with Heroku for example.
-	</longdescription>
-	<upstream>
-		<remote-id type="github">jaysonsantos/python-binary-memcached</remote-id>
-		<remote-id type="pypi">python-binary-memcached</remote-id>
-	</upstream>
-</pkgmetadata>
diff --git a/dev-python/python-binary-memcached/python-binary-memcached-0.31.1.ebuild b/dev-python/python-binary-memcached/python-binary-memcached-0.31.1.ebuild
deleted file mode 100644
index 37802aa38a..0000000000
--- a/dev-python/python-binary-memcached/python-binary-memcached-0.31.1.ebuild
+++ /dev/null
@@ -1,46 +0,0 @@
-# Copyright 1999-2022 Gentoo Authors
-# Distributed under the terms of the GNU General Public License v2
-
-EAPI=8
-
-PYTHON_COMPAT=( python3_{8..10} )
-
-inherit distutils-r1
-
-DESCRIPTION="access memcached via it's binary protocol with SASL auth support"
-HOMEPAGE="
-	https://github.com/jaysonsantos/python-binary-memcached
-	https://pypi.org/project/python-binary-memcached/
-"
-SRC_URI="https://github.com/jaysonsantos/${PN}/archive/refs/tags/v${PV}.tar.gz -> ${P}-gh.tar.gz"
-
-LICENSE="MIT"
-SLOT="0"
-KEYWORDS="~amd64"
-
-RDEPEND="
-	dev-python/six[${PYTHON_USEDEP}]
-	dev-python/uhashring[${PYTHON_USEDEP}]
-"
-DEPEND="
-	${RDEPEND}
-	>=dev-python/m2r-0.2.1[${PYTHON_USEDEP}]
-	test? ( net-misc/memcached )
-"
-BDEPEND="
-	test? (
-		dev-python/mistune[${PYTHON_USEDEP}]
-		>=dev-python/pytest-6.2[${PYTHON_USEDEP}]
-		>=dev-python/trustme-0.9.0[${PYTHON_USEDEP}]
-		>=dev-python/mock-4.0[${PYTHON_USEDEP}]
-	)
-"
-
-RESTRICT="test" # tests require a running memcached
-
-distutils_enable_tests pytest
-
-src_prepare() {
-	rm README.rst || die
-	default
-}
diff --git a/profiles/package.mask b/profiles/package.mask
index 5629afab9d..888f81dfd0 100644
--- a/profiles/package.mask
+++ b/profiles/package.mask
@@ -48,11 +48,6 @@ app-emulation/dxvk-bin
 app-editors/imhex
 dev-vcs/mergestat
 
-# Alessandro Barbieri <lssndrbarbieri@gmail.com> (2022-06-26)
-# depends on non-existent dev-python/m2r
-# https://github.com/jaysonsantos/python-binary-memcached/issues/249
-dev-python/python-binary-memcached
-
 # Christopher Byrne <salah.coronya@gmail.com> (2022-04-15)
 # Depends on masked dev-libs/openssl-3.0.*
 app-crypt/tpm2-openssl