diff --git a/profiles/package.mask b/profiles/package.mask
index 0afc4127bb..35ec0f25fc 100644
--- a/profiles/package.mask
+++ b/profiles/package.mask
@@ -65,3 +65,8 @@ net-mail/remail
 # Andrew Ammerlaan <andrewammerlaan@gentoo.org> (2022-06-18)
 # depends on non-existent dev-java/guava:20
 dev-java/gradle-hashing
+
+# Alessandro Barbieri <lssndrbarbieri@gmail.com> (2022-06-26)
+# depends on non-existent dev-python/m2r
+# https://github.com/jaysonsantos/python-binary-memcached/issues/249
+dev-python/python-binary-memcached
diff --git a/profiles/package.use.mask b/profiles/package.use.mask
index a4539c7165..7f31b8a56e 100644
--- a/profiles/package.use.mask
+++ b/profiles/package.use.mask
@@ -65,3 +65,7 @@ media-libs/skia ffmpeg
 # cmake failure
 # https://github.com/mfem/mfem/issues/2243
 sci-libs/mfem netcdf
+
+# Alessandro Barbieri <lssndrbarbieri@gmail.com> (2022-06-26)
+# depend on masked dev-python/python-binary-memcached
+dev-python/oslo-cache test