diff --git a/app-emulation/box64/box64-0.2.2.ebuild b/app-emulation/box64/box64-0.2.2.ebuild
index 1dcaf87e14..71cef82cdc 100644
--- a/app-emulation/box64/box64-0.2.2.ebuild
+++ b/app-emulation/box64/box64-0.2.2.ebuild
@@ -15,6 +15,18 @@ KEYWORDS="~arm64 ~ppc64"
 IUSE="aot"
 REQUIRED_USE="aot? ( arm64 )"
 
+pkg_setup() {
+	if [[ $(tc-endian) == big ]]; then
+		eerror "box86/box64 sadly does not support big endian systems."
+		die "big endian not supported!"
+	fi
+
+	if [[ ${CHOST} != *gnu* || ${CHOST} != *linux* ]]; then
+		eerror "box86/64 requires a glibc and a linux system. Musl support is possible, upstream welcomes PRs!"
+		die "Not a GNU+Linux system"
+	fi
+}
+
 src_configure() {
 	local -a mycmakeargs=(
 		-DNOGIT=1
diff --git a/app-emulation/box64/box64-0.3.0.ebuild b/app-emulation/box64/box64-0.3.0.ebuild
index e6b02b1257..b882fa8dcf 100644
--- a/app-emulation/box64/box64-0.3.0.ebuild
+++ b/app-emulation/box64/box64-0.3.0.ebuild
@@ -14,6 +14,18 @@ SLOT="0"
 KEYWORDS="~arm64 ~ppc64"
 IUSE="static"
 
+pkg_setup() {
+	if [[ $(tc-endian) == big ]]; then
+		eerror "box86/box64 sadly does not support big endian systems."
+		die "big endian not supported!"
+	fi
+
+	if [[ ${CHOST} != *gnu* || ${CHOST} != *linux* ]]; then
+		eerror "box86/64 requires a glibc and a linux system. Musl support is possible, upstream welcomes PRs!"
+		die "Not a GNU+Linux system"
+	fi
+}
+
 src_configure() {
 	local -a mycmakeargs=(
 		-DNOGIT=1
diff --git a/app-emulation/box64/box64-9999.ebuild b/app-emulation/box64/box64-9999.ebuild
index 91c4682ffd..6d30a199a8 100644
--- a/app-emulation/box64/box64-9999.ebuild
+++ b/app-emulation/box64/box64-9999.ebuild
@@ -14,6 +14,24 @@ SLOT="0"
 KEYWORDS=""
 IUSE="static"
 
+pkg_setup() {
+	if [[ $(tc-endian) == big ]]; then
+		eerror "box86/box64 sadly does not support big endian systems."
+		die "big endian not supported!"
+	fi
+
+	if [[ ${CHOST} != *linux* ]]; then
+		eerror "box86/64 requires a linux system."
+		die "Not a GNU+Linux system"
+	fi
+
+	if [[ ${CHOST} != *gnu* ]]; then #in case musl support is added in master branch
+		ewarn ""
+		ewarn "box86/64 will likely not build or run on a non-glibc system."
+		ewarn ""
+	fi
+}
+
 src_configure() {
 	local -a mycmakeargs=(
 		-DNOGIT=0