diff --git a/dev-python/pyvisa/Manifest b/dev-python/pyvisa/Manifest
new file mode 100644
index 0000000000..2ff8a6bfb1
--- /dev/null
+++ b/dev-python/pyvisa/Manifest
@@ -0,0 +1 @@
+DIST pyvisa-1.16.1.tar.gz 238621 BLAKE2B ad1bddc9092bdb47d9b7c12450e5e213af86794c65c8f7e6b41f688ffc9b7fa509247378dbee868be202994640760c8a9dfcab13f4d96d8644a33c158b462413 SHA512 e505cfa4a14bdf8c3177f06c4126c90361d4badffac03eca3fea46c2b235b946739eb4b098e78ab62a72269f57b49cfc93cc08d807373f29f2c98e9eb6017f6d
diff --git a/dev-python/pyvisa/metadata.xml b/dev-python/pyvisa/metadata.xml
new file mode 100644
index 0000000000..567efe4b2c
--- /dev/null
+++ b/dev-python/pyvisa/metadata.xml
@@ -0,0 +1,26 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<!DOCTYPE pkgmetadata SYSTEM "https://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+	<maintainer type="person">
+		<email>vowstar@gmail.com</email>
+		<name>Huang Rui</name>
+	</maintainer>
+	<upstream>
+		<remote-id type="github">pyvisa/pyvisa</remote-id>
+		<remote-id type="pypi">pyvisa</remote-id>
+		<doc>https://pyvisa.readthedocs.io/</doc>
+		<bugs-to>https://github.com/pyvisa/pyvisa/issues</bugs-to>
+	</upstream>
+	<longdescription lang="en">
+		PyVISA is a Python package for controlling measurement devices and test
+		equipment via GPIB, RS232, USB, and Ethernet interfaces using the VISA
+		(Virtual Instrument Software Architecture) standard. It provides a
+		unified API for communicating with instruments from various manufacturers,
+		supporting both NI-VISA and pure-Python backends.
+	</longdescription>
+	<longdescription lang="zh">
+		PyVISA是一个Python包，用于通过GPIB、RS232、USB和以太网接口使用VISA
+		（虚拟仪器软件架构）标准来控制测量设备和测试设备。它提供了统一的API，
+		用于与各个制造商的仪器进行通信，支持NI-VISA和纯Python后端。
+	</longdescription>
+</pkgmetadata>
diff --git a/dev-python/pyvisa/pyvisa-1.16.1.ebuild b/dev-python/pyvisa/pyvisa-1.16.1.ebuild
new file mode 100644
index 0000000000..e75b0d0a27
--- /dev/null
+++ b/dev-python/pyvisa/pyvisa-1.16.1.ebuild
@@ -0,0 +1,32 @@
+# Copyright 2025-2026 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{11..14} )
+DISTUTILS_USE_PEP517=setuptools
+PYPI_PN="pyvisa"
+inherit distutils-r1 pypi
+
+DESCRIPTION="Python VISA bindings for GPIB, RS232, TCPIP and USB instruments"
+HOMEPAGE="https://github.com/pyvisa/pyvisa https://pypi.org/project/pyvisa/"
+
+LICENSE="MIT"
+SLOT="0"
+KEYWORDS="~amd64"
+
+# test_visa_info requires installed entry point not available during test phase
+EPYTEST_DESELECT=(
+	pyvisa/testsuite/test_cmd_line_tools.py::TestCmdLineTools::test_visa_info
+)
+
+RDEPEND="
+	>=dev-python/typing-extensions-4.0.0[${PYTHON_USEDEP}]
+"
+BDEPEND="
+	dev-python/setuptools-scm[${PYTHON_USEDEP}]
+	${RDEPEND}
+"
+
+EPYTEST_PLUGINS=( )
+distutils_enable_tests pytest