diff --git a/dev-libs/open62541/Manifest b/dev-libs/open62541/Manifest
index 2ddc80c6c4..f62cdd2712 100644
--- a/dev-libs/open62541/Manifest
+++ b/dev-libs/open62541/Manifest
@@ -1 +1,2 @@
 DIST open62541-1.4.2.tar.gz 4197777 BLAKE2B 3b92e20b51acdff130c12cfb19d97d63f8313a3a23eef6c812bd4090aa2c89e92f8a5c6894c34b2725d25d3efcdaebb10d15caead49be4b8b9c74da1bb29f24b SHA512 145e152e4aab28e7100b518b991b47312c55cca9ece7fc9716ca09296e10d209223ee8d6da9e82543e00d536c19fbe071fcb0a43bcd5e59a0f86e798ee397596
+DIST open62541-1.4.3.tar.gz 4198524 BLAKE2B 8dbafa568381a93e2c6e5c95a51a193b63330cb980f4ea7026fb19d5c1d8519fcc345789520dbb68757a3fd9b41b19027bca4148ccc4d321f44a355365ae7ff6 SHA512 53388315eb78ad74b947f36ab92de0431c936d7a42883331e1145b5636cfcc82c45a060001296e9b45373b5755e870d3919a85f598dc441dc89bbf3da5e3f734
diff --git a/dev-libs/open62541/open62541-1.4.3.ebuild b/dev-libs/open62541/open62541-1.4.3.ebuild
new file mode 100644
index 0000000000..a4226411bf
--- /dev/null
+++ b/dev-libs/open62541/open62541-1.4.3.ebuild
@@ -0,0 +1,82 @@
+# Copyright 1999-2024 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{10..13} )
+
+inherit cmake python-single-r1
+
+DESCRIPTION="Open source C implementation of OPC UA"
+HOMEPAGE="https://www.open62541.org/"
+SRC_URI="https://github.com/${PN}/${PN}/archive/v${PV}.tar.gz -> ${P}.tar.gz"
+
+LICENSE="MPL-2.0"
+SLOT="0"
+KEYWORDS="~amd64 ~arm64 ~x86"
+IUSE="doc examples mbedtls pubsub openssl tools"
+# Requires network access
+RESTRICT="test"
+
+REQUIRED_USE="
+	${PYTHON_REQUIRED_USE}
+	?? ( mbedtls openssl )
+"
+
+BDEPEND="
+	${PYTHON_DEPS}
+	virtual/pkgconfig
+	doc? (
+		media-gfx/graphviz
+		$(python_gen_cond_dep '
+			dev-python/sphinx[${PYTHON_USEDEP}]
+			dev-python/sphinx-rtd-theme[${PYTHON_USEDEP}]
+		')
+	)
+"
+DEPEND="
+	mbedtls? ( net-libs/mbedtls:= )
+	openssl? ( dev-libs/openssl:0= )
+"
+RDEPEND="
+	${PYTHON_DEPS}
+	${DEPEND}
+"
+
+src_configure() {
+	local mycmakeargs=(
+		-DBUILD_SHARED_LIBS=ON
+		-DOPEN62541_VERSION=v${PV}
+		-DUA_BUILD_EXAMPLES=OFF
+		-DUA_BUILD_TOOLS=$(usex tools)
+		-DUA_BUILD_UNIT_TESTS=OFF
+		-DUA_ENABLE_HARDENING=OFF
+		-DUA_ENABLE_PUBSUB=$(usex pubsub)
+		-DUA_ENABLE_PUBSUB_INFORMATIONMODEL=$(usex pubsub)
+		-DUA_FORCE_WERROR=OFF
+	)
+
+	use mbedtls && mycmakeargs+=(-DUA_ENABLE_ENCRYPTION=MBEDTLS)
+	use openssl && mycmakeargs+=(-DUA_ENABLE_ENCRYPTION=OPENSSL)
+
+	cmake_src_configure
+}
+
+src_compile() {
+	cmake_src_compile
+	use doc && cmake_build doc
+}
+
+src_install() {
+	use doc && local HTML_DOCS=( "${WORKDIR}"/${P}_build/doc/. )
+	cmake_src_install
+
+	if use examples; then
+		docompress -x /usr/share/doc/${PF}/examples
+		dodoc -r examples/
+	fi
+}
+
+src_test() {
+	cmake_src_test -j1
+}