diff --git a/sci-mathematics/frama-c/Manifest b/sci-mathematics/frama-c/Manifest
new file mode 100644
index 0000000000..9681962f97
--- /dev/null
+++ b/sci-mathematics/frama-c/Manifest
@@ -0,0 +1 @@
+DIST frama-c-22.0-Titanium.tar.gz 6008520 BLAKE2B 957f1fd383913718598c8d14bd0ff4b6251cc5350633888ca061fa0e44fae17273b379dcc1b70fe8a187975364aee1f255e0df232a4ee349ff29f9cb922a7b60 SHA512 7366127da4726ffec0022adc06fd867b6ea37fc23b6a5ddccbe7562fcaa635abc6894397d0101fcb0afc339c565299c6d637006305c8331aa62a8ce734740a0f
diff --git a/sci-mathematics/frama-c/frama-c-22.0.ebuild b/sci-mathematics/frama-c/frama-c-22.0.ebuild
new file mode 100644
index 0000000000..1bb3dc8b29
--- /dev/null
+++ b/sci-mathematics/frama-c/frama-c-22.0.ebuild
@@ -0,0 +1,102 @@
+# Copyright 1999-2020 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=7
+
+inherit autotools
+
+DESCRIPTION="Framework for analysis of source codes written in C"
+HOMEPAGE="https://frama-c.com"
+NAME="Titanium"
+SRC_URI="https://frama-c.com/download/${P}-${NAME}.tar.gz"
+
+LICENSE="BSD LGPL-2 LGPL-2.1"
+SLOT="0"
+KEYWORDS="~amd64"
+IUSE="+aorai +callgraph +dive +e-acsl +eva +from-analysis gtk +impact +inout +instantiate +loop-analysis +metrics +nonterm +obfuscator +ocamlopt +occurrence +pdg +postdominators +print-api +qed +report +rtegen +scope security-slicing +semantic-constant-folding +server +slicing +sparecode +studia +users +variadic +wp"
+RESTRICT="strip"
+
+# TODO: $(use_enable markdown-report mdr) -> missing dev-ml/ppx_deriving_yojson
+
+RDEPEND="
+	>=dev-lang/ocaml-4.08.1[ocamlopt?]
+	>=dev-ml/ocamlgraph-1.8.5[gtk?,ocamlopt?]
+	>=dev-ml/zarith-1.5[ocamlopt?]
+	>=dev-ml/yojson-1.4.1[ocamlopt?]
+	gtk? ( >=dev-ml/lablgtk-2.14:2=[sourceview,gnomecanvas,ocamlopt?] )
+	wp? ( >=sci-mathematics/why3-1.3.3 )"
+DEPEND="${RDEPEND}
+	dev-ml/findlib
+	media-gfx/graphviz"
+
+REQUIRED_USE="
+	dive? ( eva studia )
+	e-acsl? ( rtegen )
+	from-analysis? ( eva callgraph )
+	impact? ( pdg eva inout )
+	inout? ( from-analysis eva callgraph )
+	metrics? ( eva )
+	nonterm? ( eva )
+	occurrence? ( eva )
+	pdg? ( from-analysis eva callgraph )
+	scope? ( postdominators eva from-analysis pdg )
+	security-slicing? ( slicing eva pdg gtk )
+	semantic-constant-folding? ( eva )
+	slicing? ( from-analysis pdg eva callgraph )
+	sparecode? ( pdg eva )
+	studia? ( eva )
+	users? ( eva )
+	wp? ( qed rtegen )"
+
+S="${WORKDIR}/${P}-${NAME}"
+
+src_prepare() {
+	mv configure.in configure.ac || die
+	sed -i 's/configure\.in/configure.ac/g' Makefile.generating Makefile || die
+	touch config_file || die
+	eautoreconf
+	eapply_user
+}
+
+src_configure() {
+	econf \
+		--disable-landmarks \
+		$(use_enable aorai) \
+		$(use_enable callgraph) \
+		$(use_enable dive) \
+		$(use_enable e-acsl) \
+		$(use_enable eva) \
+		$(use_enable from-analysis) \
+		$(use_enable gtk gui) \
+		$(use_enable impact) \
+		$(use_enable inout) \
+		$(use_enable instantiate) \
+		$(use_enable loop-analysis) \
+		--disable-mdr \
+		$(use_enable metrics) \
+		$(use_enable nonterm) \
+		$(use_enable obfuscator) \
+		$(use_enable occurrence) \
+		$(use_enable pdg) \
+		$(use_enable postdominators) \
+		$(use_enable print-api) \
+		$(use_enable qed) \
+		$(use_enable report) \
+		$(use_enable rtegen) \
+		$(use_enable scope) \
+		$(use_enable security-slicing) \
+		$(use_enable semantic-constant-folding) \
+		$(use_enable server) \
+		--disable-server-zmq \
+		$(use_enable slicing) \
+		$(use_enable sparecode) \
+		$(use_enable studia) \
+		$(use_enable users) \
+		$(use_enable variadic) \
+		$(use_enable wp) \
+		--disable-wp-coq
+}
+
+src_install() {
+	emake install DESTDIR="${ED}"
+}
diff --git a/sci-mathematics/frama-c/metadata.xml b/sci-mathematics/frama-c/metadata.xml
new file mode 100644
index 0000000000..c4798f5422
--- /dev/null
+++ b/sci-mathematics/frama-c/metadata.xml
@@ -0,0 +1,50 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+	<maintainer type="person">
+		<name>François-Xavier Carton</name>
+		<email>fx.carton91@gmail.com</email>
+	</maintainer>
+	<use>
+		<flag name="aorai">Build the Aorai plugin</flag>
+		<flag name="callgraph">Build the callgraph plugin</flag>
+		<flag name="dive">Build the Dive plugin</flag>
+		<flag name="e-acsl">Build the E-ACSL plugin</flag>
+		<flag name="eva">Build the value analysis plugin</flag>
+		<flag name="from-analysis">Build the from analysis plugin</flag>
+		<flag name="gtk">Build the graphical user interface</flag>
+		<flag name="impact">Build the impact plugin</flag>
+		<flag name="inout">Build the inout analysis plugin</flag>
+		<flag name="instantiate">Build the instantiate plugin</flag>
+		<flag name="loop-analysis">Build the loop analysis plugin</flag>
+		<flag name="metrics">Build the metrics analysis plugin</flag>
+		<flag name="nonterm">Build the nonterm plugin</flag>
+		<flag name="obfuscator">Build the Obfuscator plugin</flag>
+		<flag name="occurrence">Build the occurrence analysis plugin</flag>
+		<flag name="pdg">Build the pdg plugin</flag>
+		<flag name="postdominators">Build the postdominators plugin</flag>
+		<flag name="print-api">Build the print_api plugin</flag>
+		<flag name="qed">Build the qed plugin</flag>
+		<flag name="report">Build the report plugin</flag>
+		<flag name="rtegen">Build the runtime error annotation plugin</flag>
+		<flag name="scope">Build the scope plugin</flag>
+		<flag name="security-slicing">Build the Security slicing plugin</flag>
+		<flag name="semantic-constant-folding">Build the constant propagation plugin</flag>
+		<flag name="server">Build the Server plugin</flag>
+		<flag name="slicing">Build the slicing plugin</flag>
+		<flag name="sparecode">Build the sparecode plugin</flag>
+		<flag name="studia">Build the studia plugin</flag>
+		<flag name="users">Build the users plugin</flag>
+		<flag name="variadic">Build the variadic plugin</flag>
+		<flag name="wp">Build the WP plugin</flag>
+	</use>
+	<longdescription>
+Frama-C is a suite of tools dedicated to the analysis of the source code
+of software written in C. It gathers several static analysis techniques
+in a single collaborative framework. The collaborative approach of
+Frama-C allows static analyzers to build upon the results already
+computed by other analyzers in the framework. Thanks to this approach,
+Frama-C provides sophisticated tools, such as a slicer and dependency
+analysis.
+</longdescription>
+</pkgmetadata>